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Hyl ald-derived collagen cross-links (HLCCs) are abundant in large load-bearing skeletal tissues such as bones and cartilage and are generally more stable than LCCs (89, 92). Cross-linking pattern is also altered under pathological conditions. For detailed chemistry and biology of collagen cross-linking, see several review articles (88, 92).

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The most promising analog 5m bearing a 3-methoxy-4-morpholinophenyl substituent significantly inhibited proliferation of ALK positive H3122 and Karpas-299â ¯cells with IC50 values about 10â ¯nM, which were comparable with positive control LDK378.

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Upon excavation of the pit during location preparation, water seepage was encountered at approximately three feet. I again examined the site on January 31, 1986. Core borings in the pit revealed a water bearing sand lens at approximately five feet below normal ground level. The sand lens is approximatley 14 inches thick.

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